Gene content  |
| IL12RB2 ( by HUGO) |
| Interleukin 12 Receptor, Beta |
| Tumor suppressor gene |
| Interleukin 12 Receptor Beta 2 IL-12 Receptor Subunit Beta-2 IL-12R Subunit Beta-2 Interleukin-12 Receptor Beta-2 Chain Interleukin-12 Receptor Subunit Beta-2 IL-12R-beta-2 IL-12RB2 |
| NCBI: 1p31.3-p31.2 Ensembl: 1p31.3 |
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Subunit: Heterodimer/heterooligomer; disulfide-linked. The functional high affinity IL12 receptor is composed of I12RB1 and IL12RB2. Il12RB2 binds JAK2 (via its N-terminal) through a membrane-proximal region of the cytoplasmic domain. Interaction, in vitro and in vivo, with SOCS3 (via its SH2 domain) inhibits the STAT4-mediated activation. Binds STAT4 through a membrane-distal C-terminal region Developmental stage: Maximum levels in Th1 cells between day 3 and day 8 of activation
Tissue specificity: Isoform 2 is expressed at similar levels in both naive and activated T-cells [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including IL12RB2 (see all 6): Th17 Response in human mouse rat Interferons & Receptors in human mouse rat Th1/Th2 Respo
Function: UniProtKB/Swiss-Prot Summary: I12R2_HUMAN, Q99665 Function: Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production
Similarity: Belongs to the type I cytokine receptor family. Type 2 subfamily Contains 5 fibronectin type-III domains [IMAGE]
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