Gene content    
ING1 ( by HUGO)
Inhibitor Of Growth Family, Member 1
Tumor suppressor gene
Inhibitor Of Growth Family
Member 1
Growth Inhibitor ING1
Growth Inhibitory Protein ING1
Tumor Suppressor ING1
Inhibitor Of Growth 1
Inhibitor Of Growth Protein 1
p24ING1c
p33
p33ING1
p33ING1b
p47
p47ING1a
NCBI: 13q34    Ensembl: 13q34
ING1_HUMANSize: 422 amino acidsMass: 46738 Da

  • Subunit: Interacts with H3K4me3 and to a lesser extent with H3K4me2. Interacts with TP53 Sequence caution: Sequence=AAB60879.1; Type=Frameshift; Positions=149; Sequence=AAG02579.1; Type=Erroneous gene model prediction; 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for ING1: 2QIC (3D) [IMAGE]
  • Tissue specificity: Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and c
  • Function:
    UniProtKB/Swiss-Prot Summary: ING1_HUMAN, Q9UK53 Function: Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene
  • Similarity:
    Belongs to the ING family
                          
    Contains 1 PHD-type zinc finger [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR001965Znf_PHDZinc finger, PHD-typeDomain
    IPR011011Znf_FYVE_PHDZinc finger, FYVE/PHD-typeDomain
    BlocksIPB001965Zn-finger-likeZn-finger-like, PHD finger

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process negative regulation of cell growth NAS GOA 8944021
    Cellular Component nucleus NAS GOA 10866301
    Molecular Function methylated histone binding IDA GOA 16728974
    protein binding IPI GOA 18388957

    Disorder & Mutation    
    Source Disease
    SWISS-PROTSquamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. Note=The disease is caused by mutations affecting the gene represented in this entry

    ING1 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene