Gene content
Symbol	ING2 ( by HUGO)
Name	Inhibitor Of Growth Family, Member
Category	Tumor suppressor gene
Alias	Inhibitor Of Growth Family Member 2 ING1L Inhibitor Of Growth 1-Like Protein ING1Lp p32 p33ING2 Inhibitor Of Growth Family Member 1-Like Inhibitor Of Growth Protein 2
Cytogenetic band	NCBI: 4q35.1    Ensembl: 4q35.1
Protein information	ING2_HUMAN Size: 280 amino acids Mass: 32808 Da Subunit: Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of a mSin3A-like complex at least consisting of SIN3A, HDAC1, HDAC2, RBBP4/RbAp48, RBBP7/RbAp46, SAP30 and ING2 Tissue specificity: Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Array including ING2: Epigenetic Chromatin Remodeling Factors in human mouse rat Primer Products: [IMAGE] OriGene qPCR Function: UniProtKB/Swiss-Prot Summary: ING2_HUMAN, Q9H160 Function: Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs) Similarity: Belongs to the ING family                        Contains 1 PHD-type zinc finger [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR001965	Znf_PHD	Zinc finger, PHD-type	Domain
	IPR011011	Znf_FYVE_PHD	Zinc finger, FYVE/PHD-type	Domain
Blocks	IPB001965	Zn-finger-like	Zn-finger-like, PHD finger

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	positive regulation of transcription, DNA-templated	IDA	GOA	18334480
	positive regulation of transforming growth factor beta receptor signaling pathway	IDA	GOA	18334480
	regulation of transcription, DNA-templated	IDA	GOA	15243141
	signal transduction	TAS	GOA	10072587
Cellular Component	CCAAT-binding factor complex	IDA	GOA	15243141
	nucleus	IDA	GOA	15243141
	Sin3 complex	IDA	GOA	16387653
Molecular Function	DNA binding	IDA	GOA	15243141
	methylated histone binding	IDA	GOA	16728974
	phosphatidylinositol binding	IDA	GOA	16893883
	protein binding	IPI	GOA	18334480
	protein complex binding	IDA	GOA	18334480

ING2 cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene