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Subunit: Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. HTATTIP/TIP60, EPC1, and ING3 together constitute a minimal HAT complex termed Piccolo NuA4. Component of a SWR1-like complex Sequence caution: Sequence=AAF28979.1; Type=Frameshift; Positions=90; Sequence=AAH73865.1; Type=Miscellaneous discrepancy; Note=Intron retention; 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for ING3: 1X4I (3D) [IMAGE]
Tissue specificity: Expressed in brain, heart, kidney, liver, lung, ovaries, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including ING3: Epigenetic Chromatin Modification Enzymes in
Function: UniProtKB/Swiss-Prot Summary: ING3_HUMAN, Q9NXR8 Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome Gene Ontology (GO): 4 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0004402 contributes to histone acetyltransferase activity IDA 14966270 GO:0005515 protein binding -- -- GO:0008270 zinc ion binding IEA -- GO:0035064 methylated histone residue binding IDA 16728974 [IMAGE] Find genes that share ontologies with ING3 About GenesLikeMe Animal Models: [IMAGE] inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ING3 [IMAGE] inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ING3 [IMAGE] genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ING3 [IMAGE] genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ING3 miRNA Products: miRTarBase miRNAs that target ING3: hsa-mir-378a-5p (MIRT043992) [IMAGE] Block miRNA regulation of human, mouse, rat ING3 using miScript Target Protectors [IMAGE] Selected qRT-PCR Assays for microRNAs that regulate ING3 (see all 33): hsa-miR-596 hsa-miR-142-5p hsa-miR-3910 hsa-miR-448 hsa-miR-4288 hsa-miR-632 hsa-miR-181a-2* hsa-miR-340 [IMAGE] SwitchGear 3'UTR luciferase reporter plasmid: ING3 3' UTR sequence Inhib. RNA Products: [IMAGE] OriGene RNAi products in human, mouse, rat for ING3 [IMAGE] Predesigned siRNA for gene silencing in human, mouse, rat ING3 Gene Editing Products: [IMAGE] DNA2.0 Custom Protein Engineering Service for ING3 Clone Products: [IMAGE] OriGene clones in human, mouse for ING3 (see all 12) OriGene ORF clones in mouse, rat for ING3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling [IMAGE] GenScript: all cDNA clones in your preferred vector (see all 2): ING3 (NM_019071) [IMAGE] Browse Sino Biological Human cDNA Clones [IMAGE] DNA2.0 Custom Codon Optimized Gene Synthesis Service for ING3 [IMAGE] Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ING3 Cell Line Products: [IMAGE] GenScript Custom overexpressing Cell Line Services for ING3 [IMAGE] Browse ESI BIO Cell Lines and PureStem Progenitors for ING3 [IMAGE] In Situ Assay Products: [IMAGE] Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ING3
Similarity: Belongs to the ING family Contains 1 PHD-type zinc finger [IMAGE]
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