Gene content    
IRF2 ( by HUGO)
Interferon Regulatory Factor
Oncogene
Interferon Regulatory Factor 2
IRF-2
NCBI: 4q34.1-q35.1    Ensembl: 4q35.1
IRF2_HUMANSize: 349 amino acidsMass: 39354 Da

  • Subunit: Interacts with BRD7, IRF2BP1 and IRF2BP2. Interacts with CREBBP in growing cells; the interaction acetylates IRF2 and regulates IRF2-dependent H4 promoter activity
  • Tissue specificity: Expressed throughout the epithelium of the colon. Also expressed in lamina propria [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including IRF2: HIV Host Response in human mouse rat Interferons & Receptors in human mouse rat Type I Interferon
  • Function:
    UniProtKB/Swiss-Prot Summary: IRF2_HUMAN, P14316 Function: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation
  • Similarity:
    Belongs to the IRF family
                          
    Contains 1 IRF tryptophan pentad repeat DNA-binding domain [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR001346Interferon_reg_fact_DNA-bd_domInterferon regulatory factorDomain
    IPR011991WHTH_DNA-bd_domWinged helix repressor DNA-bindingDomain
    BlocksIPB001346Interferon regulatory factorInterferon regulatory factor

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process cell proliferation TAS GOA 8438157
    negative regulation of transcription from RNA polymerase II promoter TAS GOA 7507207
    regulation of transcription, DNA-templated IMP GOA 9540062
    Molecular Function DNA binding IDA GOA 9540062
    sequence-specific DNA binding transcription factor activity IMP GOA 9540062

    IRF2 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene