Gene content    
IRF4 ( by HUGO)
Interferon Regulatory Factor 4
Oncogene
Interferon Regulatory Factor 4
MUM1
LSIRF
Lymphocyte-Specific Interferon Regulatory Factor
Multiple Myeloma Oncogene 1
NF-EM5
IRF-4
NCBI: 6p25-p23    Ensembl: 6p25.3
IRF4_HUMANSize: 451 amino acidsMass: 51772 Da

  • Subunit: Interacts with the BATF-JUNB heterodimer. Interacts with BATF (via bZIP domain); the interaction is direct (By similarity). Interacts with SPIB and DEF6 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for IRF4: 2DLL (3D) [IMAGE]
  • Tissue specificity: Lymphoid cells [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including IRF4 (see all 10): Lung Cancer in human mouse rat Interferons & Receptors in human mouse rat Inflammasomes in human mouse rat T-cell & B-cell Activation in human mouse rat
  • Function:
    UniProtKB/Swiss-Prot Summary: IRF4_HUMAN, Q15306 Function: Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity)
  • Similarity:
    Belongs to the IRF family
                          
    Contains 1 IRF tryptophan pentad repeat DNA-binding domain [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR001346Interferon_reg_fact_DNA-bd_domInterferon regulatory factorDomain
    IPR008984SMAD_FHA_domainSMAD/FHADomain
    IPR011991WHTH_DNA-bd_domWinged helix repressor DNA-bindingDomain
    BlocksIPB001346Interferon regulatory factorInterferon regulatory factor

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process positive regulation of interleukin-10 biosynthetic process IDA GOA 12374808
    positive regulation of interleukin-13 biosynthetic process IDA GOA 12374808
    positive regulation of interleukin-2 biosynthetic process IDA GOA 12374808
    positive regulation of interleukin-4 biosynthetic process IDA GOA 12374808
    positive regulation of transcription, DNA-templated IDA GOA 12374808
    regulation of T-helper cell differentiation NAS GOA 12374808
    T cell activation NAS GOA 12374808
    Cellular Component membrane IDA GOA 19946888
    nucleus IC GOA 12374808
    Molecular Function sequence-specific DNA binding transcription factor activity NAS GOA 12374808
    transcription factor binding NAS GOA 12374808

    Disorder & Mutation    
    Source Disease
    SWISS-PROTMultiple myeloma (MM) [MIM:254500]: A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving IRF4 has been found in multiple myeloma. Translocation t(6;14)(p25;q32) with the IgH locus

    IRF4 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene