|
Subunit: Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for JTB: 2KJX (3D) [IMAGE]
Tissue specificity: Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts [IMAGE] Custom PCR Arrays for JTB Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for JTB OriGe
Function: UniProtKB/Swiss-Prot Summary: JTB_HUMAN, O76095 Function: Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity)
Similarity: Belongs to the JTB family [IMAGE]
|
