TAG for JUNB

Gene content

Symbol

JUNB ( by HUGO)

Name

Jun B Proto-Oncogene

Category

Oncogene

Alias

Jun B Proto-Oncogene
AP-1
Activator Protein 1
Transcription Factor Jun-B

Cytogenetic band

NCBI: 19p13.2 Ensembl: 19p13.2

Protein information

JUNB_HUMAN

Size: 347 amino acids

Mass: 35879 Da

Subunit: Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with ITCH (via its WW domains)

Function:

UniProtKB/Swiss-Prot Summary: JUNB_HUMAN, P17275 Function: Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'

Similarity:

Belongs to the bZIP family. Jun subfamily

Contains 1 bZIP (basic-leucine zipper) domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR002112	Leuzip_Jun	Transcription factor Jun	Family
	IPR004827	bZIP	Basic-leucine zipper (bZIP) transcription factor	Domain
	IPR005643	JNK	Jun-like transcription factor	Domain
	IPR008917	TF_DNA-bd	Eukaryotic transcription factor, DNA-binding	Domain
Blocks	IPB002112	Jun transcription factor signature	Jun transcription factor signature
Blocks	IPB005643	Jun-like transcription factor	Jun-like transcription factor

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	regulation of transcription from RNA polymerase II promoter	TAS	GOA	2513129
Cellular Component	chromatin	TAS	GOA	2513129
Molecular Function	DNA binding	TAS	GOA	10764760
	protein binding	IPI	GOA	16511568
	transcription coactivator activity	TAS	GOA	2513129
	transcription corepressor activity	TAS	GOA	2513129

JUNB cross reference