TAG for KLF6

Gene content

Symbol

KLF6 ( by HUGO)

Name

Kruppel-Like Factor 6

Category

Tumor suppressor gene

Alias

Kruppel-Like Factor 6
BCD1
COPEB
ST12
Core Promoter Element Binding Protein
GC-Rich Binding Factor
Core Promoter Element-Binding Protein
Proto-Oncogene BCD1
Suppressor Of Tumorigenicity 12 Protein
Transcription Factor Zf9
CPBP
B-Cell-Derived Protein 1
GC-Rich Sites-Binding Factor GBF
ZF9
CBA1
GBF
PAC1
Krueppel-Like Factor 6
Kruppel-Like Zinc Finger Protein Zf9
Protooncogene B-Cell Derived 1
Suppression Of Tumorigenicity 12 (Prostate)
EC 2.1.1.43
EC 6.1.1.15

Cytogenetic band

NCBI: 10p15 Ensembl: 10p15.1

Protein information

KLF6_HUMAN

Size: 283 amino acids

Mass: 31865 Da

Tissue specificity: Highly expressed in placenta followed by spleen, thymus, prostate, testis, small intestine and colon. Weakly expressed in pancreas, lung, liver, heart and skeletal muscle. Also expressed in fetal brain, spleen and thymus [IMAGE] Custom PCR Arrays for KLF6

Function:

UniProtKB/Swiss-Prot Summary: KLF6_HUMAN, Q99612 Function: Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development Enzyme Numbers (IUBMB): EC 2.1.1.432 EC 6.1.1.152 Gene Ontology (GO): 2 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding IEA -- GO:0046872 metal ion binding IEA -- [IMAGE] Find genes that share ontologies with KLF6 About GenesLikeMe Phenotypes:

Similarity:

Belongs to the krueppel C2H2-type zinc-finger protein family

Contains 3 C2H2-type zinc fingers [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR007087	Znf_C2H2	Zinc finger, C2H2-type	Domain

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	B cell differentiation	NAS	GOA	9000136
Biological Process	positive regulation of transcription, DNA-templated	TAS	GOA	9083102
Cellular Component	nucleus	TAS	GOA	9689109

Disorder & Mutation
Source	Disease
SWISS-PROT	Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. Note=The disease is caused by mutations affecting the gene represented in this entry
SWISS-PROT	Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Note=The disease is caused by mutations affecting the gene represented in this entry

KLF6 cross reference