Gene content    
KLK10 ( by HUGO)
Kallikrein-Related Peptidase 10
Tumor suppressor gene
Kallikrein-Related Peptidase 10
PRSSL1
NES1
Normal Epithelial Cell-Specific 1
Protease Serine-Like 1
Kallikrein 10
Breast Normal Epithelial Cell Associated Serine Protease
Kallikrein 10 Protein 1
Kallikrein 10 Protein 12
Kallikrein 10 Protein 2
Kallikrein 10 Protein 3
Kallikrein 10 Protein 4
Kallikrein 10 Protein 7
Kallikrein 10 Protein 8
Kallikrein 10 Protein 9
kallikrein-10
Protease
Serine-Like
1
EC 3.4.21.-
EC 3.4.21
EC 3.4.21.74
NCBI: 19q13    Ensembl: 19q13.41
KLK10_HUMANSize: 276 amino acidsMass: 30170 Da

  • Tissue specificity: Expressed in breast, ovary and prostate [IMAGE] Custom PCR Arrays for KLK10 Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for KLK10 OriGene qSTAR qPCR primer pairs in human, mouse for KLK10 [IMAGE] Pre-validated RT2 qPCR Primer
  • Function:
    UniProtKB/Swiss-Prot Summary: KLK10_HUMAN, O43240 Function: Has a tumor-suppressor role for NES1 in breast and prostate cancer Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.742 EC 3.4.21.-1 Gene Ontology (GO): 3 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0003824 catalytic activity -- -- GO:0004252 serine-type endopeptidase activity IEA -- GO:0008236 serine-type peptidase activity TAS 8764136 [IMAGE] Find genes that share ontologies with KLK10 About GenesLikeMe Animal Models: [IMAGE] inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLK10 [IMAGE] inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KLK10 [IMAGE] genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLK10 [IMAGE] genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLK10 miRNA Products: miRTarBase miRNAs that target KLK10: hsa-mir-224-5p (MIRT000454), hsa-mir-375 (MIRT019672), hsa-let-7f-5p (MIRT000455) [IMAGE] Block miRNA regulation of human, mouse, rat KLK10 using miScript Target Protectors [IMAGE] Selected qRT-PCR Assays for microRNAs that regulate KLK10 (see all 15): hsa-miR-194* hsa-miR-4265 hsa-miR-582-3p hsa-miR-140-5p hsa-miR-516b* hsa-miR-646 hsa-miR-1262 hsa-miR-214 [IMAGE] SwitchGear 3'UTR luciferase reporter plasmid: KLK10 3' UTR sequence Inhib. RNA Products: [IMAGE] OriGene RNAi products in human, mouse, rat for KLK10 [IMAGE] Predesigned siRNA for gene silencing in human, mouse, rat KLK10 Gene Editing Products: [IMAGE] DNA2.0 Custom Protein Engineering Service for KLK10 Clone Products: [IMAGE] OriGene clones in human, mouse for KLK10 (see all 14) OriGene ORF clones in mouse, rat for KLK10 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling [IMAGE] GenScript: all cDNA clones in your preferred vector (see all 3): KLK10 (NM_002776) [IMAGE] Sino Biological Human cDNA Clone for KLK10 [IMAGE] DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLK10 [IMAGE] Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK10 Cell Line Products: [IMAGE] GenScript Custom overexpressing Cell Line Services for KLK10 [IMAGE] Browse ESI BIO Cell Lines and PureStem Progenitors for KLK10 [IMAGE] In Situ Assay Products: [IMAGE] Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK10
  • Similarity:
    Belongs to the peptidase S1 family. Kallikrein subfamily
                          
    Contains 1 peptidase S1 domain [IMAGE]
  • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR001254Peptidase_S1Peptidase S1 and S6, chymotrypsin/HapDomain
    IPR001314Peptidase_S1APeptidase S1A, chymotrypsinDomain
    IPR009003Trypsin-like_Pept_domPeptidase, trypsin-like serine and cysteine proteasesDomain
    BlocksIPB001254Serine proteaseSerine protease, trypsin family
    IPB001314Chymotrypsin serine protease family (S1) signatureChymotrypsin serine protease family (S1) signature

    Gene Ontology    
    Type Term Evidence Source Pub
    Molecular Function serine-type peptidase activity TAS GOA 8764136

    KLK10 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene