Gene content    
LAF4 (approved by HUGO)
AF4/FMR2 family, member 3
Oncogene
LAF4
MLLT2-like
NCBI: 2q11.2-q12    Ensembl: 2q11.2
AFF3_HUMANSize: 1227 amino acidsMass: 133734 Da

  • Subcellular location: Nucleus
  • Tissue specificity: Preferentially expressed in lymphoid tissues, highest levels being found in the thymus
  • Function:
    Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double- stranded DNA
  • Similarity:
    Belongs to the AF4 family.

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR007797AF-4AF-4 proto-oncoproteinFamily
    BlocksIPB007797AF-4 proto-oncoproteinAF-4 proto-oncoprotein

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process development TAS GOA PubMed
    DNA binding IEA GOA
    nucleus TAS GOA PubMed
    Molecular Function regulation of transcription, DNA-dependent IEA GOA
    transcription IEA GOA

    LAF4 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene