Gene content
Symbol	LAMC2 ( by HUGO)
Name	Laminin, Gamma
Category	Oncogene
Alias	Laminin Gamma 2 LAMB2T LAMNB2 EBR2 EBR2A Cell-Scattering Factor 140 KDa Subunit Epiligrin Subunit Gamma Kalinin Subunit Gamma Ladsin 140 KDa Subunit Laminin B2t Chain Large Adhesive Scatter Factor 140 KDa Subunit Nicein Subunit Gamma CSF 140 KDa Subunit Laminin Gamma 2 (Nicein (100kD) Kalinin (105kD) BM600 (100kD) Herlitz Junctional Epidermolysis Bullosa)) B2T BM600 BM600-100kDa CSF Laminin Subunit Gamma-2 Kalinin/Nicein/Epiligrin 100 KDa Subunit Laminin-5 Subunit Gamma
Cytogenetic band	NCBI: 1q25-q31    Ensembl: 1q25.3
Protein information	LAMC2_HUMAN Size: 1193 amino acids Mass: 130976 Da Subunit: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Gamma-2 is a subunit of laminin-5 (laminin-332 or epiligrin/kalinin/nicein) Miscellaneous: Binds heparin (By similarity) Tissue specificity: The large variant is expressed only in specific epithelial cells of embryonic and neonatal tissues. In 17-week old embryo the small variant is found in cerebral cortex, lung, and distal tubes of kidney, but not in epithelia except for distal tubuli [IMAGE Function: UniProtKB/Swiss-Prot Summary: LAMC2_HUMAN, Q13753 Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells Similarity: Contains 8 laminin EGF-like domains                        Contains 1 laminin IV type A domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000034	Laminin_B_type_IV	Laminin B	Domain
	IPR002049	EGF_laminin	Laminin-type EGF-like	Domain
Blocks	IPB000034	Laminin B	Laminin B

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	epidermis development	TAS	GOA	8012394

Disorder & Mutation
Source	Disease
SWISS-PROT	Epidermolysis bullosa, junctional, Herlitz type (H-JEB) [MIM:226700]: An infantile and lethal form of junctional epidermolysis bullosa, a group of blistering skin diseases characterized by tissue separation which occurs within the dermo-epidermal basement In the Herlitz type, death occurs usually within the first six months of life. Occasionally, children survive to teens. It is marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may be hemorrhagic. Note=The disease is caused by mutations affecting the gene represented in this entry

LAMC2 cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene