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Tissue specificity: Heart, placenta, skeletal muscle, kidney, lung and pancreas [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including LOX: Fibrosis in human mouse rat Polycomb & Trithorax Target Genes in human mouse rat Hypoxia Signaling Pathway in human mouse
Function: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression
Catalytic activity: Peptidyl-L-lysyl-peptide + O(2) + H(2)O = peptidyl-allysyl-peptide + NH(3) + H(2)O(2)
Similarity: Belongs to the lysyl oxidase family [IMAGE]
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