Gene content
Symbol	LPL ( by HUGO)
Name	Lipoprotein Lipase
Category	Tumor suppressor gene
Alias	Lipoprotein Lipase LIPD EC 3.1.1.34 HDLCQ11 EC 3.1.1
Cytogenetic band	NCBI: 8p22    Ensembl: 8p21.3
Protein information	LIPL_HUMAN Size: 475 amino acids Mass: 53162 Da Subunit: Homodimer (By similarity). Interacts with APOC2; the interaction activates LPL activity in the presence of lipids. Interacts with GPIHBP1 Function: The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity)                        The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity) Catalytic activity: Triacylglycerol + H(2)O = diacylglycerol + a carboxylate Similarity: Belongs to the AB hydrolase superfamily. Lipase family                        Contains 1 PLAT domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000734	Lipase	Lipase	Family
	IPR001024	PLAT/LH2_dom	Lipoxygenase, LH2	Domain
	IPR002330	Lipo_Lipase	Lipoprotein lipase	Family
	IPR008976	Lipase_LipOase	Lipase/lipooxygenase, PLAT/LH2	Domain
Blocks	IPB000734	Lipase	Lipase
	IPB001024	Lipoxygenase	Lipoxygenase, LH2 domain
	IPB002330	Lipoprotein lipase signature	Lipoprotein lipase signature
	IPB008262	Lipase	Lipase, active site

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	chylomicron remodeling	IC	GOA	3973011
	fatty acid biosynthetic process	IDA	GOA	182536
	fatty acid biosynthetic process	IC	GOA	3973011
	phospholipid metabolic process	ISS	GOA	10727238
	positive regulation of cholesterol storage	IMP	GOA	12573449
	positive regulation of macrophage derived foam cell differentiation	IC	GOA	12573449
	positive regulation of sequestering of triglyceride	IMP	GOA	12573449
	triglyceride catabolic process	IDA	GOA	182536
	triglyceride homeostasis	IGI	GOA	17018885
	triglyceride metabolic process	ISS	GOA	10727238
	very-low-density lipoprotein particle remodeling	IDA	GOA	3973011
Cellular Component	extracellular space	IDA	GOA	12573449
Molecular Function	apolipoprotein binding	IPI	GOA	15178420
	heparin binding	IDA	GOA	12573449
	lipoprotein lipase activity	ISS	GOA	10727238
	lipoprotein lipase activity	IDA	GOA	3973011
	phospholipase activity	ISS	GOA	10727238
	receptor binding	IPI	GOA	10085125
	triglyceride lipase activity	ISS	GOA	10727238
	triglyceride lipase activity	IDA	GOA	12573449

Disorder & Mutation
Source	Disease
Genatlas	human blood pressure QTL at or near the lipoprotein lipase gene,accounting for 52-73% of variation in systolic bp in the data set (Taiwanese population)

LPL cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene