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Tissue specificity: Expressed in osteoblast cell lines. Well expressed in ovary, heart, pancreas, skeletal muscle, lung, and fetal kidney and lung and only at the basal levels in the other tissues examined including adult kidney. More expressed in S-type neuroblastoma cells
Function: UniProtKB/Swiss-Prot Summary: LRC17_HUMAN, Q8N6Y2 Function: Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similarity) Gene Ontology (GO): 1 molecular function term: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding -- -- [IMAGE] Find genes that share ontologies with LRRC17 About GenesLikeMe Phenotypes:
Similarity: Contains 6 LRR (leucine-rich) repeats Contains 2 LRRCT domains Contains 1 LRRNT domain [IMAGE]
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