Gene content    
LYL1 ( by HUGO)
Lymphoblastic Leukemia Associated Hematopoiesis Regulator...
Oncogene
Lymphoblastic Leukemia Associated Hematopoiesis Regulator 1
Lymphoblastic Leukemia Derived Sequence 1
Class A Basic Helix-Loop-Helix Protein 18
bHLHa18
Protein Lyl-1
BHLHA18
Lymphoblastic Leukemia-Derived Sequence 1
NCBI: 19p13.2    Ensembl: 19p13.2
LYL1_HUMANSize: 280 amino acidsMass: 29938 Da

  • Subunit: Efficient DNA binding requires dimerization with another bHLH protein Sequence caution: Sequence=AAA88084.1; Type=Erroneous initiation; Sequence=AAA88085.1; Type=Erroneous initiation; Sequence=AAA92488.1; Type=Erroneous initiation;
  • Function:
    Genatlas biochemistry entry for LYL1: DNA binding protein with helix loop helix motif,rearranged in T-ALL leukemia,with translocation t(7;19) Gene Ontology (GO): 3 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding IDA 18160048 GO:0005515 protein binding IPI 10023675 GO:0046983 protein dimerization activity IEA -- [IMAGE] Find genes that share ontologies with LYL1 About GenesLikeMe Phenotypes:
  • Similarity:
    Contains 1 bHLH (basic helix-loop-helix) domain [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR011598bHLH_domHelix-loop-helix DNA-bindingDomain
    BlocksIPB001092Basic helix-loop-helix dimerization domain bHLHBasic helix-loop-helix dimerization domain bHLH

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process positive regulation of transcription, DNA-templated IDA GOA 18160048
    regulation of transcription, DNA-templated IDA GOA 10023675
    Molecular Function DNA binding IDA GOA 18160048
    protein binding IPI GOA 10023675

    Disorder & Mutation    
    Source Disease
    Genatlasacute lymphoblastic leukemia (T-ALL) with translocation t(7;19)(q35;p13) Tumor Gene Database (TGDB): LYL1 Export disorders for LYL1 gene to outside databases
    SWISS-PROTNote=A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;19)(q35;p13) with TCRB

    LYL1 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene