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Subunit: Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23 Sequence caution: Sequence=BAB47442.1; Type=Erroneous initiation;
Tissue specificity: Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon [IMAGE] Custom PCR Arrays for LZTS2 Primer Products: [IMAGE] OriGene qSTAR qPCR primer pairs in human, mouse for LZTS2 [IMAGE] Pre-v
Function: UniProtKB/Swiss-Prot Summary: LZTS2_HUMAN, Q9BRK4 Function: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin
Similarity: Belongs to the LZTS2 family [IMAGE]
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