Gene content    
MAFB ( by HUGO)
V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog...
Oncogene
V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog B
KRML
MCTO
Kreisler (Mouse) Maf-Related Leucine Zipper Homolog
Kreisler Maf-Related Leucine Zipper Homolog
MAFB/Kreisler Basic Region/Leucine Zipper Transcription Factor
Transcription Factor MafB
Maf-B
V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog B
NCBI: 20q11.2-q13.1    Ensembl: 20q12
MAFB_HUMANSize: 323 amino acidsMass: 35792 Da

  • Subunit: Homodimer or heterodimer with other bHLH-Zip transcription factors. Binds DNA as a homodimer or a heterodimer. Forms homodimers and heterodimers with FOS, FOSB and FOSL2, but not with JUN proteins (JUN, JUNB and JUND). Interacts with PAX6; the interaction is direct. Interacts with ETS1 and LRP1 (By similarity). Interacts with the intracellular cytoplasmic domain of LRP1 (LRPICD); the interaction results in a moderate reduction of MAFB transcriptional potential
  • Tissue specificity: Ubiquitous [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including MAFB: Terminal Differentiation Markers in human mouse rat Cancer Drug Resistance in human mouse rat Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards fo
  • Function:
    UniProtKB/Swiss-Prot Summary: MAFB_HUMAN, Q9Y5Q3 Function: Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context Gene Ontology (GO): 5 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding -- -- GO:0003700 sequence-specific DNA binding transcription factor activity IEA -- GO:0005515 protein binding IPI 10698492 GO:0008134 transcription factor binding IDA 10698492 GO:0043565 sequence-specific DNA binding IEA -- [IMAGE] Find genes that share ontologies with MAFB About GenesLikeMe Phenotypes: 1 GenomeRNAi human phenotype for MAFB: Increased gamma-H2AX phosphory
  • Similarity:
    Belongs to the bZIP family. Maf subfamily
                          
    Contains 1 bZIP (basic-leucine zipper) domain [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR004826bZIP_MafMaf transcription factorDomain
    IPR004827bZIPBasic-leucine zipper (bZIP) transcription factorDomain
    IPR008917TF_DNA-bdEukaryotic transcription factor, DNA-bindingDomain

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process negative regulation of erythrocyte differentiation IDA GOA 8620536
    sensory organ development TAS GOA 8001130
    Molecular Function protein binding IPI GOA 10698492
    transcription factor binding IDA GOA 10698492

    Disorder & Mutation    
    Source Disease
    SWISS-PROTMulticentric carpotarsal osteolysis syndrome (MCTO) [MIM:166300]: A rare skeletal disorder, usually presenting in early childhood with a clinical picture mimicking juvenile rheumatoid arthritis. Progressive destruction of the carpal and tarsal bone usually occurs and other bones may also be involved. Chronic renal failure is a frequent component of the syndrome. Mental retardation and minor facial anomalies have been noted in some patients. Note=The disease is caused by mutations affecting the gene represented in this entry

    MAFB cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene