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Subunit: Homodimer. Heterodimer with MAPRE3. Interacts with DCTN1, DCTN2, DIAPH1, DIAPH2, TERF1 and dynein intermediate chain. Interacts with APC (via C-terminal domain), CLASP2, DST, KIF2C and STIM1; probably required for their targeting to the growing microtubule plus ends. Interacts with MTUS2; interaction is direct and probably targets MTUS2 to microtubules. Interacts with APC2. Interacts with CLASP1. Interacts with CDK5RAP2. Interacts with MACF1 (By similarity). Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 (By similarity). Interacts (via C-terminus) with CLIP1. Interacts with SLAIN2. Interacts with KIF18B; this interaction is required for efficient accumulation of KIF18B at microtubule plus ends. Interacts with MISP Selected PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for MAPRE1 (see all 14): 1PA7 (3D) [IMAGE] 1TXQ (3D) [IMAGE] 1UEG (3D) [IMAGE] 1VKA (3D) [IMAGE] 1WU9 (3D) [IMAGE] 1YIB (3D) [IMAGE]
Tissue specificity: Ubiquitously expressed [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPRE1: Cytoskeleton Regulators in human mouse rat Adherens Junctions in human mouse rat Telomeres & Telomerase in human mouse rat Primer Products: [IMAGE] OriGene
Function: UniProtKB/Swiss-Prot Summary: MARE1_HUMAN, Q15691 Function: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration
Similarity: Belongs to the MAPRE family Contains 1 CH (calponin-homology) domain Contains 1 EB1 C-terminal domain [IMAGE]
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