Gene content
Symbol	MAS1 ( by HUGO)
Name	MAS1 Oncogene
Category	Oncogene
Alias	MAS1 Oncogene MAS MGRA Mas-Related G Protein-Coupled Receptor A Proto-Oncogene Mas
Cytogenetic band	NCBI: 6q25.3-q26    Ensembl: 6q25.3
Protein information	MAS_HUMAN Size: 325 amino acids Mass: 37465 Da Subunit: Interacts with AGTR1 (Probable) Caution: Was originally (PubMed:3419518) thought to be a receptor for angiotensin II Function: UniProtKB/Swiss-Prot Summary: MAS_HUMAN, P04201 Function: Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1 Similarity: Belongs to the G-protein coupled receptor 1 family [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000276	GPCR_Rhodpsn	Rhodopsin-like GPCR superfamily	Family
	IPR000820	Proto-oncogene_Mas	Mas transmembrane protein	Family
Blocks	IPB000820	Mas oncogene signature	Mas oncogene signature

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	anatomical structure morphogenesis	TAS	GOA	8661154
	cell proliferation	TAS	GOA	3419518
	G-protein coupled receptor signaling pathway	TAS	GOA	3419518
	protein kinase C signaling	IMP	GOA	16611642
Cellular Component	integral component of plasma membrane	TAS	GOA	3419518
	plasma membrane	IDA	GOA	16611642
Molecular Function	angiotensin type II receptor activity	TAS	GOA	3419518
	G-protein coupled receptor activity	IDA	GOA	16611642

MAS1 cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene