|
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MYC or MAD. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with SPAG9. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity 5 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for MAX: 1AN2 (3D) [IMAGE] 1HLO (3D) [IMAGE] 1NKP (3D) [IMAGE] 1NLW (3D) [IMAGE] 1R05 (3D) [IMAGE]
Tissue specificity: High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including MAX: G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse
Function: UniProtKB/Swiss-Prot Summary: MAX_HUMAN, P61244 Function: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity
Similarity: Belongs to the MAX family Contains 1 bHLH (basic helix-loop-helix) domain [IMAGE]
|
