Gene content
Symbol	MCC ( by HUGO)
Name	Mutated In Colorectal Cancers
Category	Tumor suppressor gene & --
Alias	Mutated In Colorectal Cancers MCC1 Colorectal Mutant Cancer Protein Protein MCC
Cytogenetic band	NCBI: 5q21    Ensembl: 5q22.2
Protein information	CRCM_HUMAN Size: 829 amino acids Mass: 93027 Da Subunit: Interacts with SCRIB (via phosphorylated PDZ-binding motif), EZR, SNX27, SLC9A3R1 and SLC9A3R2. Interacts with CTNNB1; the interaction is enhanced upon Wnt stimulation. Interacts with MYH10 Tissue specificity: Expressed in a variety of tissues [IMAGE] Custom PCR Arrays for MCC Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for MCC OriGene qSTAR qPCR primer pairs in human, mouse for MCC [IMAGE] Pre-validated RT2 qPCR Primer Assay in hu Function: UniProtKB/Swiss-Prot Summary: CRCM_HUMAN, P23508 Function: Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation Similarity: Belongs to the MCC family [IMAGE]

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	calcium ion binding	IEA	GOA
	cell cycle	IEA	GOA
	negative regulation of progression through cell cycle	IEA	GOA
	protein binding	IPI	GOA	PubMed
	receptor activity	TAS	GOA	PubMed
Molecular Function	signal transduction	TAS	GOA	PubMed

MCC cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene