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Subunit: Interacts with CCPG1, which results in specific inhibition of its exchange activity toward RHOA (By similarity). Interacts with an array of inositol phospholipids such as phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4-phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P) Sequence caution: Sequence=BAA20817.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAM24069.3; Type=Erroneous gene model prediction; Sequence=CAM24070.1; Type=Erroneous gene model prediction;
Function: UniProtKB/Swiss-Prot Summary: MCF2L_HUMAN, O15068 Function: Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 Gene Ontology (GO): 3 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA -- GO:0005515 protein binding -- -- GO:0005545 1-phosphatidylinositol binding IEA -- [IMAGE] Find genes that share ontologies with MCF2L About GenesLikeMe Phenotypes: 1 GenomeRNAi human phenotype for MCF2L: Increased gamma-H2AX phosphory
Similarity: Belongs to the MCF2 family Contains 1 CRAL-TRIO domain Contains 1 DH (DBL-homology) domain Contains 1 PH domain Contains 1 SH3 domain Contains 1 spectrin repeat [IMAGE]
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