TAG for MEIS1

Gene content

Symbol

MEIS1 ( by HUGO)

Name

Meis Homeobox 1

Category

Oncogene

Alias

Meis Homeobox 1
Meis1 (Mouse) Homolog
Meis1
Myeloid Ecotropic Viral Integration Site 1 Homolog (Mouse)
WUGSC:H_NH0444B04.1
Homeobox Protein Meis1
Leukemogenic Homolog Protein
Meis1
Myeloid Ecotropic Viral Integration Site 1 Homolog

Cytogenetic band

NCBI: 2p14 Ensembl: 2p14

Protein information

MEIS1_HUMAN

Size: 390 amino acids

Mass: 43016 Da

Subunit: Interacts with the N-terminal region of PBX1 to form a heterodimer which binds DNA including a cAMP-responsive sequence in CYP17. Also forms heterodimers with PBX2. Forms heterotrimers with PBX1 or PBX2 and a number of HOX proteins including HOXA9, HOXD4 and HOXD9 where it acts as a non-DNA-binding partner. Also forms heterotrimers with PBX1 and HOX proteins including HOXD9 and HOXD10 where PBX1 is the non-DNA-binding partner

Tissue specificity: Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high leve

Function:

UniProtKB/Swiss-Prot Summary: MEIS1_HUMAN, O00470 Function: Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias

Similarity:

Belongs to the TALE/MEIS homeobox family

Contains 1 homeobox DNA-binding domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR001356	Homeobox_dom	Homeobox	Domain
	IPR008422	Homeobox_KN_domain	Coprinus cinereus mating-type protein	Family
	IPR009057	Homeodomain-like	Homeodomain-like	Domain

Gene Ontology
Type	Term	Evidence	Source	Pub
Molecular Function	protein binding	IPI	GOA	18692240

Disorder & Mutation
Source	Disease
SWISS-PROT	Restless legs syndrome 7 (RLS7) [MIM:612853]: A neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. The majority of patients also have periodic limb movements in sleep, which are characterized by involuntary, highly stereotypical, regularly occurring limb movements that occur during sleep. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry

MEIS1 cross reference