Gene content    
MFGE8 ( by HUGO)
Milk Fat Globule-EGF Factor 8 Protein
Other
Milk Fat Globule-EGF Factor 8 Protein
SPAG10
Sperm Associated Antigen 10
Sperm Surface Protein HP47
Breast Epithelial Antigen BA46
HMFG
MFG-E8
MFGM
SED1
BA46
EDIL1
HsT19888
OAcGD3S
hP47
lactadherin
medin
O-Acetyl Disialoganglioside Synthase
Milk Fat Globule-EGF Factor 8
NCBI: 15q25    Ensembl: 15q26.1
MFGM_HUMANSize: 387 amino acidsMass: 43123 Da

  • Tissue specificity: Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas [IMAGE] Custom PCR Arrays for MFGE8 Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for MFGE8 OriGene qSTAR qPCR primer pairs in human, mouse
  • Function:
    UniProtKB/Swiss-Prot Summary: MFGM_HUMAN, Q08431 Function: Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication Function: Medin is the main constituent of aortic medial amyloid
  • Similarity:
    Contains 1 EGF-like domain
                          
    Contains 2 F5/8 type C domains [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR000421Coagulation_fac_5/8-C_type_domCoagulation factor 5/8 type, C-terminalDomain
    IPR000742EG-like_domEGF-like, subtype 2Domain
    IPR008979Galactose-bd-likeGalactose-binding likeDomain
    IPR013032EGF-like_CSEGF-like regionDomain
    BlocksIPB000421Coagulation factor 5/8 type C domain (FA58C)Coagulation factor 5/8 type C domain (FA58C)
    IPB000421Coagulation factor 5/8 type C domain (FA58C) IPB001438 Type II EGF-like signature IPB006210 Type I EGFCoagulation factor 5/8 type C domain (FA58C)

    Gene Ontology    
    Type Term Evidence Source Pub
    Cellular Component extracellular space IDA GOA 16502470
    extracellular vesicular exosome IDA GOA 19056867
    membrane IDA GOA 19946888

    MFGE8 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene