Gene content
Symbol	MGP ( by HUGO)
Name	Matrix Gla Protein
Category	Other
Alias	Matrix Gla Protein Cell Growth-Inhibiting Gene 36 Protein MGLAP NTI
Cytogenetic band	NCBI: 12p12.3    Ensembl: 12p12.3
Protein information	MGP_HUMAN Size: 103 amino acids Mass: 12353 Da Function: UniProtKB/Swiss-Prot Summary: MGP_HUMAN, P08493 Function: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation Similarity: Belongs to the osteocalcin/matrix Gla protein family                        Contains 1 Gla (gamma-carboxy-glutamate) domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000294	GLA_domain	Vitamin K-dependent carboxylation/gamma-carboxyglutamic region	Domain
	IPR002384	Osteocalcin/MGP	Bone matrix, Gla region	Domain

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	cartilage condensation	TAS	GOA	9916809
Cellular Component	extracellular vesicular exosome	IDA	GOA	19199708
	proteinaceous extracellular matrix	TAS	GOA	9916809
Molecular Function	extracellular matrix structural constituent	TAS	GOA	9916809
	structural constituent of bone	TAS	GOA	9916809

Disorder & Mutation
Source	Disease
SWISS-PROT	Keutel syndrome (KS) [MIM:245150]: Autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia. Note=The disease is caused by mutations affecting the gene represented in this entry

MGP cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene