|
Subunit: Interacts with CENPU. Also interacts with NRBP1/MADM, YWHAZ/14-3-3-zeta and HNRPUL2/MANP. NRBP1 recruits a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 then binds to YWHAZ and is retained in the cytoplasm. Retained in the nucleus by binding to HNRPUL2. Binds to COPS3/CSN3 which is required for suppression of RFWD2 and activation of p53 2 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for MLF1: 3UAL (3D) [IMAGE] 3UBW (3D) [IMAGE]
Tissue specificity: Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes [IMAGE] Custom PCR Arrays for MLF1 Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for MLF
Function: UniProtKB/Swiss-Prot Summary: MLF1_HUMAN, P58340 Function: Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus
Similarity: Belongs to the MLF family [IMAGE]
|
