Gene content    
MLLT1 ( by HUGO)
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog,...
Other
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog
Drosophila); Translocated To
1
ENL
LTG19
YEATS1
YEATS Domain-Containing Protein 1
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila) Homolog); Translocated To
1
CTC-503J8.6
ENL/MLL Fusion
MLLT1/MLL Fusion
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog); Translocated To
1
Protein ENL
NCBI: 19p13.3    Ensembl: 19p13.3
ENL_HUMANSize: 559 amino acidsMass: 62056 Da

  • Subunit: Component of the super elongation complex (SEC), at least composed of AFF4, the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Interacts with ALKBH4
  • Function:
    UniProtKB/Swiss-Prot Summary: ENL_HUMAN, Q03111 Function: Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA
  • Similarity:
    Contains 1 YEATS domain [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR005033YEATSYEATSFamily
    BlocksIPB005033YEATS familyYEATS family

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process transcription from RNA polymerase II promoter TAS GOA 8080983
    Molecular Function DNA binding TAS GOA 7991593

    Disorder & Mutation    
    Source Disease
    SWISS-PROTNote=A chromosomal aberration involving MLLT1 is associated with acute leukemias. Translocation t(11;19)(q23;p13.3) with KMT2A/MLL1. The result is a rogue activator protein

    MLLT1 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene