TAG for MLLT11

Gene content

Symbol

MLLT11 ( by HUGO)

Name

Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog,...

Category

Oncogene

Alias

Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog
Drosophila); Translocated To
11
AF1Q
ALL1 Fused Gene From Chromosome 1q
ALL1-Fused Gene From Chromosome 1q
Protein AF1q

Cytogenetic band

NCBI: 1q21 Ensembl: 1q21.3

Protein information

AF1Q_HUMAN

Size: 90 amino acids

Mass: 10061 Da

Tissue specificity: Highly expressed in thymus and all leukemic cell lines [IMAGE] Custom PCR Arrays for MLLT11 Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for MLLT11 OriGene qSTAR qPCR primer pairs in human, mouse for MLLT11 [IMAGE] Pre-validat

Similarity:

Belongs to the MLLT11 family [IMAGE]

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	positive regulation of apoptotic process	IMP	GOA	18852119
	positive regulation of mitochondrial depolarization	IDA	GOA	18852119
	positive regulation of release of cytochrome c from mitochondria	IDA	GOA	18852119
	positive regulation of transcription, DNA-templated	IDA	GOA	18852119
Cellular Component	intracellular	IDA	GOA	18852119

Disorder & Mutation
Source	Disease
SWISS-PROT	Note=A chromosomal aberration involving MLLT11 is found in acute leukemias. Translocation t(1;11)(q21;q23) with KMT2A/MLL1

MLLT11 cross reference