TAG for MLLT3

Gene content

Symbol

MLLT3 ( by HUGO)

Name

Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog,...

Category

Oncogene

Alias

Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog
Drosophila); Translocated To
3
AF9
Myeloid/Lymphoid Or Mixed-Lineage Leukemia Translocated To Chromosome 3 Protein
YEATS3
ALL1-Fused Gene From Chromosome 9 Protein
YEATS Domain-Containing Protein 3
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila) Homolog); Translocated To
3
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog); Translocated To
3
Protein AF-9

Cytogenetic band

NCBI: 9p22 Ensembl: 9p21.3

Protein information

AF9_HUMAN

Size: 568 amino acids

Mass: 63351 Da

Subunit: Component of the super elongation complex (SEC), at least composed of EAF1, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Interacts with BCOR. Interacts with ALKBH4 and CBX8 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for MLLT3: 2LM0 (3D) [IMAGE]

Function:

UniProtKB/Swiss-Prot Summary: AF9_HUMAN, P42568 Function: Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA

Similarity:

Contains 1 YEATS domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR005033	YEATS	YEATS	Family
Blocks	IPB005033	YEATS family	YEATS family

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	negative regulation of canonical Wnt signaling pathway	IGI	GOA	19591803
	negative regulation of canonical Wnt signaling pathway	IDA	GOA	19591803
	positive regulation of Wnt signaling pathway, planar cell polarity pathway	IGI	GOA	19591803
Cellular Component	extracellular vesicular exosome	IDA	GOA	19056867
Cellular Component	nucleus	TAS	GOA	8506309

Disorder & Mutation
Source	Disease
SWISS-PROT	Note=A chromosomal aberration involving MLLT3 is associated with acute leukemias. Translocation t(9;11)(p22;q23) with KMT2A/MLL1. The result is a rogue activator protein

MLLT3 cross reference