Gene content    
MLLT6 ( by HUGO)
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog,...
Other
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog
Drosophila); Translocated To
6
AF17
Trithorax Homolog
ALL1-Fused Gene From Chromosome 17 Protein
6
Myeloid/Lymphoid Or Mixed-Lineage Leukemia
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila) Homolog); Translocated To
6
Translocated To
Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog); Translocated To
6
Myeloid/Lymphoid Or Mixed-Lineage Leukemia
Translocated To
6
Protein AF-17
NCBI: 17q21    Ensembl: 17q12
AF17_HUMANSize: 1093 amino acidsMass: 112076 Da

  • Function:
    Genatlas biochemistry entry for MLLT6: AF-17 protein,fused with HRX (MLL),in acute lymphoblastic leukemia and monoblastic leukemia with granulocytic sarcomas,with translocation t(11;17)(q23;q21),may be the same as TCF11 Gene Ontology (GO): 2 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding IPI 16713569 GO:0008270 zinc ion binding IEA -- [IMAGE] Find genes that share ontologies with MLLT6 About GenesLikeMe Phenotypes:
  • Similarity:
    Contains 2 PHD-type zinc fingers [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR001965Znf_PHDZinc finger, PHD-typeDomain
    IPR011011Znf_FYVE_PHDZinc finger, FYVE/PHD-typeDomain
    BlocksIPB001965Zn-finger-likeZn-finger-like, PHD finger

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process regulation of transcription, DNA-templated TAS GOA 8058765
    Molecular Function protein binding IPI GOA 16713569

    Disorder & Mutation    
    Source Disease
    SWISS-PROTNote=A chromosomal aberration involving MLLT6 is associated with acute leukemias. Translocation t(11;17)(q23;q21) with KMT2A/MLL1. The result is a rogue activator protein

    MLLT6 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene