Gene content    
MLLT7 (approved by HUGO)
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7
Other
AFX
AFX1
FOXO4
MGC120490
NCBI: Xq13.1    Ensembl: Xq13.1
FOXO4_HUMANSize: 505 amino acidsMass: 53758 Da

  • Subcellular location: Nucleus (Potential)
  • Tissue specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform zeta is most abundant in the liver, kidney, and pancreas
  • Function:
    Plays a role in the insulin signaling pathway
  • Similarity:
    Contains 1 fork-head DNA-binding domain

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR001766TF_Fork_headFork head transcription factorDomain
    IPR011991Wing_hlx_DNA_bdWinged helix repressor DNA-bindingDomain

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process cell cycle IEA GOA
    enzyme binding IPI GOA PubMed
    G1 phase of mitotic cell cycle IDA GOA PubMed
    negative regulation of angiogenesis IDA GOA PubMed
    negative regulation of cell proliferation IDA GOA PubMed
    negative regulation of smooth muscle cell differentiation IDA GOA PubMed
    nucleus IDA GOA PubMed
    transcription factor binding IPI GOA PubMed
    Cellular Component striated muscle development IEA GOA
    Molecular Function cell cycle arrest IDA GOA PubMed
    cell differentiation IEA GOA
    cytosol IDA GOA PubMed
    insulin receptor signaling pathway IDA GOA PubMed
    regulation of transcription, DNA-dependent IDA GOA PubMed
    transcription IEA GOA
    transcription from RNA polymerase II promoter TAS GOA PubMed

    Disorder & Mutation    
    Source Disease
    SWISS-PROTA chromosomal aberration involving MLLT7 is found in acute leukemias. Translocation t(X;11)(q13;q23) with MLL/HRX. The result is a rogue activator protein

    MLLT7 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene