Gene content    
MPL ( by HUGO)
Myeloproliferative Leukemia Virus Oncogene
Oncogene
Myeloproliferative Leukemia Virus Oncogene
TPOR
Myeloproliferative Leukemia Protein
Proto-Oncogene C-Mpl
TPO-R
MPLV
THCYT2
C-MPL
CD110
Thrombopoietin Receptor
CD110 Antigen
NCBI: 1p34    Ensembl: 1p34.2
TPOR_HUMANSize: 635 amino acidsMass: 71245 Da

  • Subunit: Interacts with ATXN2L Caution: It is uncertain whether Met-1 or Met-8 is the initiator
  • Tissue specificity: Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including MPL: Interferons & Receptors in human mouse rat JAK
  • Function:
    UniProtKB/Swiss-Prot Summary: TPOR_HUMAN, P40238 Function: Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses
  • Similarity:
    Belongs to the type I cytokine receptor family. Type 1 subfamily
                          
    Contains 2 fibronectin type-III domains [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR003528Long_hematopoietin_rcpt_CSLong hematopoietin receptor, single chainFamily
    IPR003961Fibronectin_type3Fibronectin, type IIIDomain

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process cell proliferation TAS GOA 8020956
    cell surface receptor signaling pathway TAS GOA 8020956
    Cellular Component integral component of plasma membrane TAS GOA 8020956
    Molecular Function transmembrane signaling receptor activity TAS GOA 8020956

    Disorder & Mutation    
    Source Disease
    SWISS-PROTCongenital amegakaryocytic thrombocytopenia (CAMT) [MIM:604498]: Disease characterized by isolated thrombocytopenia and megakaryocytopenia with no physical anomalies. Note=The disease is caused by mutations affecting the gene represented in this entry
    SWISS-PROTThrombocythemia 2 (THCYT2) [MIM:601977]: A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes. Note=The disease is caused by mutations affecting the gene represented in this entry

    MPL cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene