Gene content    
MSH3 ( by HUGO)
MutS Homolog 3
Other
MutS Homolog 3
Divergent Upstream Protein
Mismatch Repair Protein 1
DUP
MRP1
hMSH3
MutS (E. Coli) Homolog 3
MutS Homolog 3 (E. Coli)
DNA Mismatch Repair Protein Msh3
DUC1
DUG
NCBI: 5q11-q12    Ensembl: 5q14.1
MSH3_HUMANSize: 1137 amino acidsMass: 127412 Da

  • Subunit: Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1). Interacts with EXO1 Sequence caution: Sequence=AAH11817.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; 4 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for MSH3: 3THW (3D) [IMAGE] 3THX (3D) [IMAGE] 3THY (3D) [IMAGE] 3THZ (3D) [IMAGE]
  • Function:
    UniProtKB/Swiss-Prot Summary: MSH3_HUMAN, P20585 Function: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis
  • Similarity:
    Belongs to the DNA mismatch repair MutS family. MSH3 subfamily [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR000432DNA_mismatch_repair_MutS_CDNA mismatch repair protein MutS, C-terminalDomain
    IPR007695DNA_mismatch_repair_MutS-lik_NDNA mismatch repair protein MutS, N-terminalDomain
    IPR007696DNA_mismatch_repair_MutS_coreMutS IIIDomain
    IPR007860DNA_mmatch_repair_MutS_con_domMutS IIDomain
    IPR007861DNA_mismatch_repair_MutS_clampMutS IVDomain
    BlocksIPB007695DNA mismatch repair protein MutSDNA mismatch repair protein MutS, N-terminal
    IPB007696MutS IIIMutS III

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process DNA repair IDA GOA 8942985
    maintenance of DNA repeat elements IMP GOA 16388310
    mismatch repair IMP GOA 8782829
    negative regulation of DNA recombination IDA GOA 17715146
    positive regulation of helicase activity IDA GOA 17715146
    Cellular Component membrane IDA GOA 19946888
    MutSbeta complex IDA GOA 8942985
    Molecular Function contributes_to dinucleotide insertion or deletion binding IDA GOA 8942985
    contributes_to dinucleotide repeat insertion binding IDA GOA 8942985
    contributes_to mismatched DNA binding IDA GOA 8942985
    contributes_to single guanine insertion binding IDA GOA 8942985
    contributes_to single-stranded DNA binding IDA GOA 11809883
    enzyme binding IPI GOA 11427529
    NOT contributes_to oxidized purine DNA binding IDA GOA 11756455
    NOT guanine/thymine mispair binding IDA GOA 11809883
    NOT protein homodimerization activity IDA GOA 8942985
    protein binding IPI GOA 11005803

    Disorder & Mutation    
    Source Disease
    SWISS-PROTEndometrial cancer (ENDMC) [MIM:608089]: A malignancy of endometrium, the mucous lining of the uterus. Most endometrial cancers are adenocarcinomas, cancers that begin in cells that make and release mucus and other fluids. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry

    MSH3 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene