Gene content    
MTUS1 ( by HUGO)
Microtubule Associated Tumor Suppressor 1
Tumor suppressor gene
Microtubule Associated Tumor Suppressor 1
Mitochondrial Tumor Suppressor 1
AT2 Receptor-Interacting Protein
AT2R Binding Protein
Mitochondrial Tumor Suppressor Gene 1
Angiotensin-II Type 2 Receptor-Interacting Protein
ATBP
ATIP
MTSG1
AT2 Receptor-Binding Protein
ICIS
MP44
Erythroid Differentiation-Related
Microtubule-Associated Tumor Suppressor 1
Transcription Factor MTSG1
GK1
KIAA1288
NCBI: 8p22    Ensembl: 8p22
MTUS1_HUMANSize: 1270 amino acidsMass: 141397 Da

  • Subunit: Homodimer. Interacts with AGTR2. Interacts with PTPN6 (By similarity). Isoform 1 associates with microtubules Sequence caution: Sequence=AAH07328.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAH33842.1; Type=Erroneous initiation; Sequence=BAB14894.1; Type=Erroneous initiation;
  • Tissue specificity: Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Is
  • Function:
    UniProtKB/Swiss-Prot Summary: MTUS1_HUMAN, Q9ULD2 Function: Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth

    • Disorder & Mutation    
    Source Disease
    SWISS-PROTHepatocellular carcinoma (HCC) [MIM:114550]: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. Note=The gene represented in this entry may be involved in disease pathogenesis

    MTUS1 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene