TAG for MXI1

Gene content

Symbol

MXI1 ( by HUGO)

Name

MAX Interactor 1, Dimerization Protein

Category

Tumor suppressor gene

Alias

MAX Interactor 1
Dimerization Protein
Max Interactor 1
Class C Basic Helix-Loop-Helix Protein 11
bHLHc11
MAX Interacting Protein 1
MAD2
MXD2
MXI
MAX Dimerization Protein 2
Max-Interacting Protein 1
Max-Related Transcription Factor
BHLHC11

Cytogenetic band

NCBI: 10q24-q25 Ensembl: 10q25.2

Protein information

MXI1_HUMAN

Size: 228 amino acids

Mass: 26062 Da

Subunit: Interacts with SMC3 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with RNF17 (By similarity)

Tissue specificity: High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Array including MXI1: Hypoxia Signaling Pathway in human mouse rat Primer Products: [IMA

Function:

UniProtKB/Swiss-Prot Summary: MXI1_HUMAN, P50539 Function: Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX

Similarity:

Contains 1 bHLH (basic helix-loop-helix) domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR011598	bHLH_dom	Helix-loop-helix DNA-binding	Domain
Blocks	IPB001092	Basic helix-loop-helix dimerization domain bHLH	Basic helix-loop-helix dimerization domain bHLH

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	cytoplasmic sequestering of transcription factor	TAS	GOA	8425219
Biological Process	negative regulation of cell proliferation	TAS	GOA	9624006
Molecular Function	transcription corepressor activity	TAS	GOA	8425219

Disorder & Mutation
Source	Disease
SWISS-PROT	Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry

MXI1 cross reference