Gene content    
MYBL1 ( by HUGO)
V-Myb Avian Myeloblastosis Viral Oncogene Homolog-Like 1
Oncogene
V-Myb Avian Myeloblastosis Viral Oncogene Homolog-Like 1
Myb-Like Protein 1
AMYB
A-MYB
Myb-Related Protein A
V-Myb Myeloblastosis Viral Oncogene Homolog-Like 1
A-Myb
NCBI: 8q22    Ensembl: 8q13.1
MYBA_HUMANSize: 752 amino acidsMass: 85887 Da

  • Subunit: Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2
  • Tissue specificity: Expressed in a variety of lymphoid and solid tumor lines cultured in vitro [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Array including MYBL1: Lymphoma in human mouse rat Primer Products: [IMAGE] OriGene qSTAR qPCR primer pairs in human, mouse for M
  • Function:
    UniProtKB/Swiss-Prot Summary: MYBA_HUMAN, P10243 Function: Strong transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and B-lymphoid cells
  • Similarity:
    Contains 3 HTH myb-type DNA-binding domains [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR001005SANT/MybMyb, DNA-bindingDomain
    IPR009057Homeodomain-likeHomeodomain-likeDomain
    IPR012642Tscrpt_reg_Wos2-domainMitotic Wos2Domain
    BlocksIPB001005Myb DNA-binding domainMyb DNA-binding domain

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process positive regulation of transcription from RNA polymerase II promoter IDA GOA 7987850
    positive regulation of transcription, DNA-templated NAS GOA 8058310
    Cellular Component nucleus NAS GOA 8058310
    Molecular Function RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA GOA 7987850
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA GOA 7987850

    MYBL1 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene