Gene content    
MYBL2 ( by HUGO)
V-Myb Avian Myeloblastosis Viral Oncogene Homolog-Like
Oncogene
V-Myb Avian Myeloblastosis Viral Oncogene Homolog-Like 2
BMYB
Myb-Like Protein 2
B-MYB
Myb-Related Protein B
V-Myb Myeloblastosis Viral Oncogene Homolog-Like 2
B-Myb
NCBI: 20q13.1    Ensembl: 20q13.12
MYBB_HUMANSize: 700 amino acidsMass: 78764 Da

  • Subunit: Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL22
  • Function:
    UniProtKB/Swiss-Prot Summary: MYBB_HUMAN, P10244 Function: Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene
  • Similarity:
    Contains 3 HTH myb-type DNA-binding domains [IMAGE]
  • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR001005SANT/MybMyb, DNA-bindingDomain
    IPR009057Homeodomain-likeHomeodomain-likeDomain
    BlocksIPB001005Myb DNA-binding domainMyb DNA-binding domain

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process positive regulation of transcription from RNA polymerase II promoter IDA GOA 10770937
    Molecular Function protein binding IPI GOA 17159899
    RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA GOA 10770937
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA GOA 10770937
    sequence-specific DNA binding transcription factor activity TAS GOA 10770937

    MYBL2 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene