Gene content    
MYC ( by HUGO)
V-Myc Avian Myelocytomatosis Viral Oncogene Homolog
Oncogene
V-Myc Avian Myelocytomatosis Viral Oncogene Homolog
Class E Basic Helix-Loop-Helix Protein 39
Proto-Oncogene C-Myc
Transcription Factor P64
bHLHe39
MRTL
MYCC
Avian Myelocytomatosis Viral Oncogene Homolog
c-Myc
Myc Proto-Oncogene Protein
Myc-Related Translation/Localization Regulatory Factor
V-Myc Myelocytomatosis Viral Oncogene Homolog
BHLHE39
NCBI: 8q24.21    Ensembl: 8q24.21
MYC_HUMANSize: 439 amino acidsMass: 48804 Da

  • Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7. Interacts with PIM2. Interacts with NO66. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity Biotechnology: POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes 6 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for MYC: 1A93 (3D) [IMAGE] 1EE4 (3D) [IMAGE] 1MV0 (3D) [IMAGE] 1NKP (3D) [IMAGE] 2A93 (3D) [IMAGE] 2OR9 (3D) [IMAGE]
  • Function:
    UniProtKB/Swiss-Prot Summary: MYC_HUMAN, P01106 Function: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes
  • Similarity:
    Contains 1 bHLH (basic helix-loop-helix) domain [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR002418Tscrpt_reg_MycTranscription regulator MycFamily
    IPR003327Myc-LZLeucine zipper, MycDomain
    IPR011598bHLH_domHelix-loop-helix DNA-bindingDomain
    IPR012682Tscrpt_reg_Myc_NTranscription regulator Myc, N-terminalDomain
    BlocksIPB001092Basic helix-loop-helix dimerization domain bHLHBasic helix-loop-helix dimerization domain bHLH
    IPB002418Myc proto-oncogene signatureMyc proto-oncogene signature
    IPB003327Leucine zipperLeucine zipper, Myc

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process cell cycle arrest IDA GOA 10962037
    cellular iron ion homeostasis IDA GOA 9924025
    cellular response to DNA damage stimulus IDA GOA 17873522
    cellular response to UV IEP GOA 17873522
    chromosome organization IDA GOA 10962037
    energy reserve metabolic process NAS GOA 9924025
    fibroblast apoptotic process TAS GOA 10962037
    MAPK cascade IMP GOA 17873522
    negative regulation of cell division IDA GOA 10962037
    negative regulation of fibroblast proliferation IDA GOA 10962037
    negative regulation of monocyte differentiation IMP GOA 9924025
    negative regulation of transcription from RNA polymerase II promoter IDA GOA 9924025
    oxygen transport NAS GOA 9924025
    positive regulation of cell proliferation IDA GOA 15994933
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA GOA 19179467
    positive regulation of epithelial cell proliferation IDA GOA 18987311
    positive regulation of fibroblast proliferation IMP GOA 15674325
    positive regulation of fibroblast proliferation IDA GOA 18987311
    positive regulation of transcription from RNA polymerase II promoter IMP GOA 9924025
    positive regulation of transcription from RNA polymerase II promoter IDA GOA 10723141
    positive regulation of transcription, DNA-templated IDA GOA 10962037
    regulation of telomere maintenance IMP GOA 17765874
    response to drug IEP GOA 18291362
    response to gamma radiation IDA GOA 19179467
    response to growth factor TAS GOA 18987311
    Cellular Component nucleolus IDA GOA 17558397
    nucleoplasm IDA GOA 17558397
    nucleus IDA GOA 11793365
    protein complex IDA GOA 17873522
    Molecular Function DNA binding TAS GOA 10597290
    E-box binding IDA GOA 18818310
    protein binding IPI GOA 10597290
    protein complex binding IDA GOA 18987311
    repressing transcription factor binding IPI GOA 15674325
    RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA GOA 10723141
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA GOA 10723141
    sequence-specific DNA binding transcription factor activity IDA GOA 9924025
    transcription factor binding IPI GOA 15674325

    Disorder & Mutation    
    Source Disease
    GenatlasBurkitt lymphoma/acute lymphoblastic leukemia,B cell,with translocations t(8;14)(q24;q32),t(2;8)(p12;q24),t(8;22)(q24;q11); (see also BVR1,PVT1)
    SWISS-PROTNote=Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors
    SWISS-PROTNote=A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1

    MYC cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene