Gene content    
NCOA4 ( by HUGO)
Nuclear Receptor Coactivator 4
Other
Nuclear Receptor Coactivator 4
ELE1
RET-Activating Gene ELE1
Androgen Receptor-Associated Protein Of 70 KDa
70 KDa Androgen Receptor Coactivator
70 KDa AR-Activator
ARA70
NCoA-4
RFG
PTC3
Ret Fused
Androgen Receptor Coactivator 70 KDa Protein
Ret-Activating Protein ELE1
NCBI: 10q11.2    Ensembl: 10q11.23
NCOA4_HUMANSize: 614 amino acidsMass: 69726 Da

  • Subunit: Interacts with the androgen receptor and the retinoid X receptor (RXR) in a ligand-dependent manner 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for NCOA4: 1T5Z (3D) [IMAGE]
  • Tissue specificity: Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform Beta is only expressed in testis [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Array including NCOA4: Nuclear Receptors & Coregulators in human mouse rat Primer P
  • Function:
    UniProtKB/Swiss-Prot Summary: NCOA4_HUMAN, Q13772 Function: Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma

    • Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process androgen receptor signaling pathway NAS GOA 15572661
    male gonad development TAS GOA 8643607
    positive regulation of transcription, DNA-templated NAS GOA 15572661
    Cellular Component nucleus TAS GOA 8643607
    Molecular Function androgen receptor binding NAS GOA 15572661
    transcription coactivator activity NAS GOA 15572661

    Disorder & Mutation    
    Source Disease
    SWISS-PROTThyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving NCOA4 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene that has been found in sporadic and radiation-associated post-Chernobyl thyroid papillary carcinomas

    NCOA4 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene