|
Subunit: Interacts with CIAPIN1. Interacts with DCPS Miscellaneous: Overexpression enhanced cytotoxicity of menadione, and consequently induced cell death, coexpression with DCPS reduced this toxicity 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for NDOR1: 4H2D (3D) [IMAGE]
Tissue specificity: Low expression in brain, heart, kidney, pancreas, prostate and skeletal muscle. Highest levels in the placenta. Expressed in cancer cell lines including promyelocytic leukemia, HeLaS3, chronic myelagenous leukemia, lymphoblastic leukemia, Burkitt's lympho
Function: UniProtKB/Swiss-Prot Summary: NDOR1_HUMAN, Q9UHB4 Function: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins (By similarity). Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1 Biophysicochemical properties: Kinetic parameters: KM=21 uM for cytochrome c; Vmax=1.2 umol/min/ug enzyme for cytochrome c reduction; pH dependence: Optimum pH is about 8.0; Enzyme Number (IUBMB): EC 1.6.-.-1 Gene Ontology (GO): Selected molecular function terms (see all 8): About this table GO ID Qualified GO term Evidence PubMed IDs GO:0003958 NADPH-hemoprotein reductase activity IBA -- GO:0005506 iron ion binding IEA -- GO:0005515 protein binding IPI 16140270 GO:0010181 FMN binding IDA 10625700 GO:0016491 oxidoreductase activity IDA 10625700 [IMAGE] Find genes that share ontologies with NDOR1 About GenesLikeMe Animal Models: [IMAGE] inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NDOR1 [IMAGE] inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NDOR1 [IMAGE] genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NDOR1 [IMAGE] genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NDOR1 miRNA Products: miRTarBase miRNAs that target NDOR1: hsa-mir-125b-5p (MIRT045962), hsa-mir-18a-3p (MIRT040948) [IMAGE] Block miRNA regulation of human, mouse, rat NDOR1 using miScript Target Protectors [IMAGE] Selected qRT-PCR Assays for microRNAs that regulate NDOR1 (see all 29): hsa-miR-4291 hsa-miR-132* hsa-miR-1250 hsa-miR-15a hsa-miR-424 hsa-miR-296-5p hsa-miR-195 hsa-miR-15b [IMAGE] SwitchGear 3'UTR luciferase reporter plasmid: NDOR1 3' UTR sequence Inhib. RNA Products: [IMAGE] OriGene RNAi products in human, mouse, rat for NDOR1 [IMAGE] Predesigned siRNA for gene silencing in human, mouse, rat NDOR1 Gene Editing Products: [IMAGE] DNA2.0 Custom Protein Engineering Service for NDOR1 Clone Products: [IMAGE] OriGene clones in human, mouse for NDOR1 (see all 18) OriGene ORF clones in mouse, rat for NDOR1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling [IMAGE] GenScript: all cDNA clones in your preferred vector (see all 4): NDOR1 (NM_014434) [IMAGE] Sino Biological Human cDNA Clone for NDOR1 [IMAGE] DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDOR1 [IMAGE] Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDOR1 Cell Line Products: [IMAGE] GenScript Custom overexpressing Cell Line Services for NDOR1 [IMAGE] Browse ESI BIO Cell Lines and PureStem Progenitors for NDOR1 [IMAGE] In Situ Assay Products: [IMAGE] Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDOR1
Similarity: Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family Contains 1 FAD-binding FR-type domain Contains 1 flavodoxin-like domain [IMAGE]
|
