TAG for NDRG1

Gene content

Symbol

NDRG1 ( by HUGO)

Name

N-Myc Downstream Regulated 1

Category

Tumor suppressor gene

Alias

N-Myc Downstream Regulated 1
CAP43
Differentiation-Related Gene 1 Protein
Nickel-Specific Induction Protein Cap43
Reducing Agents And Tunicamycin-Responsive Protein
DRG-1
DRG1
RTP
N-Myc Downstream-Regulated Gene 1 Protein
CMT4D
HMSNL
GC4
NDR1
NMSL
PROXY1
RIT42
TARG1
TDD5
Protein NDRG1
Protein Regulated By Oxygen-1
Rit42

Cytogenetic band

NCBI: 8q24.3 Ensembl: 8q24.22

Protein information

NDRG1_HUMAN

Size: 394 amino acids

Mass: 42835 Da

Subunit: Interacts with RAB4A (membrane-bound form); the interaction involves NDRG1 in vesicular recycling of CDH1

Tissue specificity: Ubiquitous; expressed most prominently in placental membranes and prostate, kidney, small intestine, and ovary tissues. Also expressed in heart, brain, skeletal muscle, lung, liver and pancreas. Low levels in peripheral blood leukocytes and in tissues of

Function:

UniProtKB/Swiss-Prot Summary: NDRG1_HUMAN, Q92597 Function: Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy

Similarity:

Belongs to the NDRG family [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR004142	Ndr	Ndr	Family
Blocks	IPB004142	Ndr family	Ndr family

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	DNA damage response, signal transduction by p53 class mediator	IEP	GOA	9766676
	positive regulation of spindle checkpoint	IDA	GOA	15247272
	response to metal ion	TAS	GOA	9605764
Cellular Component	cell-cell adherens junction	IDA	GOA	12432451
	centrosome	IDA	GOA	15247272
	extracellular vesicular exosome	IDA	GOA	19056867
	microtubule	IDA	GOA	15247272
	nucleus	IDA	GOA	9766676
	perinuclear region of cytoplasm	IDA	GOA	17786215
	plasma membrane	IDA	GOA	12432451
	recycling endosome membrane	IDA	GOA	17786215
Molecular Function	cadherin binding	IDA	GOA	17786215
	gamma-tubulin binding	IDA	GOA	15247272
	microtubule binding	IDA	GOA	15247272
	protein binding	IPI	GOA	17220478
	Rab GTPase binding	IDA	GOA	17786215

Disorder & Mutation
Source	Disease
SWISS-PROT	Charcot-Marie-Tooth disease 4D (CMT4D) [MIM:601455]: A recessive demyelinating form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Demyelinating neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4. Note=The disease is caused by mutations affecting the gene represented in this entry

NDRG1 cross reference