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Subunit: Complex I is composed of 45 different subunits. Interacts with CARD15, but not with CARD4. Interacts with STAT3, but not with STAT1, STAT2 and STAT5A. Interacts with HHV-8 IRF1, in the nucleus, with HPV-16 E6 and SV40 LT. Interacts with OLFM4 Developmental stage: Expressed in numerous fetal tissues Sequence caution: Sequence=AAD27748.1; Type=Erroneous initiation; Sequence=AAG44670.1; Type=Erroneous initiation; Sequence=AAH00589.2; Type=Erroneous initiation;
Tissue specificity: Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Array includ
Function: UniProtKB/Swiss-Prot Summary: NDUAD_HUMAN, Q9P0J0 Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes
Similarity: Belongs to the complex I NDUFA13 subunit family [IMAGE]
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