Gene content    
NEO1 ( by HUGO)
Neogenin 1
Tumor suppressor gene
Neogenin 1
NGN
Immunoglobulin Superfamily DCC Subclass Member 2
IGDCC2
DCC Subclass
Immunoglobulin Superfamily
Member 2
Neogenin (Chicken) Homolog 1
neogenin
Neogenin Homolog 1
NCBI: 15q22.3-q23    Ensembl: 15q24.1
NEO1_HUMANSize: 1461 amino acidsMass: 160017 Da

  • Subunit: Interacts with RGMA. Interacts with MYO10 (By similarity) Selected PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for NEO1 (see all 7): 1X5F (3D) [IMAGE] 1X5G (3D) [IMAGE] 1X5H (3D) [IMAGE] 1X5I (3D) [IMAGE] 1X5J (3D) [IMAGE] 1X5K (3D) [IMAGE]
  • Tissue specificity: Widely expressed and also in cancer cell lines [IMAGE] Custom PCR Arrays for NEO1 Primer Products: [IMAGE] OriGene qSTAR qPCR primer pairs in human, mouse for NEO1 [IMAGE] Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NEO1 [IMAGE] QuantiTect SY
  • Function:
    UniProtKB/Swiss-Prot Summary: NEO1_HUMAN, Q92859 Function: May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues
  • Similarity:
    Belongs to the immunoglobulin superfamily. DCC family
                          
    Contains 6 fibronectin type-III domains
                          
    Contains 4 Ig-like C2-type (immunoglobulin-like) domains [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR003598Ig_sub2Immunoglobulin C2 typeDomain
    IPR003599Ig_subImmunoglobulin subtypeDomain
    IPR003961Fibronectin_type3Fibronectin, type IIIDomain
    IPR007110Ig-like_domImmunoglobulin-likeDomain
    IPR010560Neogenin_CNeogenin, C-terminalDomain
    IPR013098Ig_I-setImmunoglobulin I-setDomain
    BlocksIPB003598Immunoglobulin C-2 typeImmunoglobulin C-2 type
    IPB003962Fibronectin type III repeat signatureFibronectin type III repeat signature
    IPB010560NeogeninNeogenin, C-terminal

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process iron ion homeostasis IGI GOA 16075058
    Cellular Component integral component of plasma membrane TAS GOA 9169140

    NEO1 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene