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Subunit: Interacts with RHOA in its GTP- and GDP-bound states, and with CDC42 in its GTP-bound state. Interacts with the PDZ 1 domain of BAIAP1 (By similarity) Sequence caution: Sequence=AAB08847.1; Type=Frameshift; Positions=586; Sequence=AAB37683.1; Type=Frameshift; Positions=15, 33; Sequence=CAA08974.1; Type=Frameshift; Positions=8, 55, 59, 70, 586; 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for NET1: 3EO2 (3D) [IMAGE]
Tissue specificity: Widely expressed [IMAGE] Custom PCR Arrays for NET1 Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for NET1 OriGene qSTAR qPCR primer pairs in human, mouse for NET1 [IMAGE] Pre-validated RT2 qPCR Primer Assay in human, mouse, ra
Function: UniProtKB/Swiss-Prot Summary: ARHG8_HUMAN, Q7Z628 Function: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death
Similarity: Contains 1 DH (DBL-homology) domain Contains 1 PH domain [IMAGE]
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