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Subunit: Interacts with serum response factor (SRF) (By similarity). Interacts with SPDEF. Interacts with WDR77. Interacts with TOPORS which polyubiquitinates NKX3-1 and induces its proteasomal degradation 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for NKX3-1: 2L9R (3D) [IMAGE]
Tissue specificity: Highly expressed in the prostate and, at a lower level, in the testis [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including NKX3-1: Prostate Cancer in human mouse rat Homeobox (HOX) Genes in human mouse rat Primer Products: [IMAGE] OriGene q
Function: UniProtKB/Swiss-Prot Summary: NKX31_HUMAN, Q99801 Function: Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells
Similarity: Belongs to the NK-3 homeobox family Contains 1 homeobox DNA-binding domain [IMAGE]
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