TAG for NOV

Gene content

Symbol

NOV ( by HUGO)

Name

Nephroblastoma Overexpressed

Category

Oncogene

Alias

Nephroblastoma Overexpressed
Insulin-Like Growth Factor-Binding Protein 9
Nephroblastoma-Overexpressed Gene Protein Homolog
CCN3
IBP-9
IGFBP-9
IGFBP9
CCN Family Member 3
IGF-Binding Protein 9
Nephroblastoma Overexpressed Gene
NOVh
Protein NOV Homolog
NOVH
NovH

Cytogenetic band

NCBI: 8q24.1 Ensembl: 8q24.12

Protein information

NOV_HUMAN

Size: 357 amino acids

Mass: 39162 Da

Subunit: Interacts with FBLN1

Tissue specificity: Expressed in bone marrow, thymic cells and nephroblastoma. Increased expression in Wilms tumor of the stromal type [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including NOV: Estrogen Receptor Signaling in human mouse rat Gap Junctions in hum

Function:

UniProtKB/Swiss-Prot Summary: NOV_HUMAN, P48745 Function: Immediate-early protein likely to play a role in cell growth regulation (By similarity)

Similarity:

Belongs to the CCN family

Contains 1 CTCK (C-terminal cystine knot-like) domain

Contains 1 IGFBP N-terminal domain

Contains 1 TSP type-1 domain

Contains 1 VWFC domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000867	IGFBP-like	Insulin-like growth factor-binding protein, IGFBP	Domain
	IPR000884	Thrombospondin_1_rpt	Thrombospondin, type I	Repeat
	IPR001007	VWF_C	von Willebrand factor, type C	Domain
	IPR006207	Cys_knot_C	Cystine knot, C-terminal	Domain
	IPR006208	Cys_knot	Cystine knot	Domain
	IPR009030	Growth_fac_rcpt_N_dom	Growth factor, receptor	Domain
	IPR012395	IGFBP_CNN	IGFBP-related, CNN	Family
Blocks	IPB000867	Insulin-like growth factor-binding protein	Insulin-like growth factor-binding protein, IGFBP
	IPB000884	Thrombospondin	Thrombospondin, type I
	IPB001007	von Willebrand factor	von Willebrand factor, type C
	IPB006207	Cystine knot	Cystine knot, C-terminal
	IPB006208	Cystine knot domain	Cystine knot domain

NOV cross reference