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Subunit: Forms a heterodimer with NPRL3. Interacts with PDPK1. Within the GATOR complex, component of the GATOR1 subcomplex, made of DEPDC5, NPRL2 and NPRL3. GATOR1 mediates the strong interaction of the GATOR complex with RRAGA/RRAGC and RRAGB/RRAGC heterodimers
Tissue specificity: Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested [IMAGE] Custom PCR Arrays for NPRL2 Primer Products: [IMAGE] OriGene qPCR prim
Function: UniProtKB/Swiss-Prot Summary: NPRL2_HUMAN, Q8WTW4 Function: Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs. As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling Gene Ontology (GO): 3 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0004672 protein kinase activity IDA 18616680 GO:0005096 GTPase activator activity IEA -- GO:0005515 protein binding IPI 18616680 [IMAGE] Find genes that share ontologies with NPRL2 About GenesLikeMe Animal Models: [IMAGE] inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NPRL2 [IMAGE] inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NPRL2 [IMAGE] genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NPRL2 [IMAGE] genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NPRL2 miRNA Products: miRTarBase miRNAs that target NPRL2: hsa-mir-26b-5p (MIRT029030) [IMAGE] Block miRNA regulation of human, mouse, rat NPRL2 using miScript Target Protectors [IMAGE] 1 qRT-PCR Assays for microRNA that regulate NPRL2: hsa-miR-203 [IMAGE] Browse SwitchGear 3'UTR luciferase reporter plasmids Inhib. RNA Products: [IMAGE] OriGene RNAi products in human, mouse, rat for NPRL2 [IMAGE] Predesigned siRNA for gene silencing in human, mouse, rat NPRL2 Gene Editing Products: [IMAGE] DNA2.0 Custom Protein Engineering Service for NPRL2 Clone Products: [IMAGE] OriGene clones in human, mouse for NPRL2 (see all 8) OriGene ORF clones in mouse, rat for NPRL2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling [IMAGE] GenScript: all cDNA clones in your preferred vector: NPRL2 (NM_006545) [IMAGE] Browse Sino Biological Human cDNA Clones [IMAGE] DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPRL2 [IMAGE] Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPRL2 [IMAGE] Addgene plasmids for NPRL2 [IMAGE] Cell Line Products: [IMAGE] GenScript Custom overexpressing Cell Line Services for NPRL2 [IMAGE] Browse ESI BIO Cell Lines and PureStem Progenitors for NPRL2 [IMAGE] In Situ Assay Products: [IMAGE] Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPRL2
Similarity: Belongs to the NPR2 family [IMAGE]
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