Gene content
Symbol	NRAS ( by HUGO)
Name	Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog
Category	Oncogene
Alias	Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog Transforming Protein N-Ras ALPS4 NS6 N-ras NRAS1 GTPase NRas N-Ras Protein Part 4 V-Ras Neuroblastoma RAS Viral Oncogene Homolog HRAS1
Cytogenetic band	NCBI: 1p13.2    Ensembl: 1p13.2
Protein information	RASN_HUMAN Size: 189 amino acids Mass: 21229 Da Subunit: Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts (active GTP-bound form) with RASSF7 Miscellaneous: Mutations which change AA 12, 13 or 61 activate the potential of Ras to transform cultured cells and are implicated in a variety of human tumors 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for NRAS: 3CON (3D) [IMAGE] Function: UniProtKB/Swiss-Prot Summary: RASN_HUMAN, P01111 Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity Enzyme regulation: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP) Similarity: Belongs to the small GTPase superfamily. Ras family [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR001806	Small_GTPase	Ras GTPase	Family
	IPR005225	Small_GTP-bd_dom	Small GTP-binding protein domain	Domain
Blocks	IPB001806	Transforming protein P21 RAS signature	Transforming protein P21 RAS signature
	IPB003577	Ras small GTPase	Ras small GTPase, Ras type

Gene Ontology
Type	Term	Evidence	Source	Pub
Cellular Component	membrane	IDA	GOA	19946888

Disorder & Mutation
Source	Disease
SWISS-PROT	Noonan syndrome 6 (NS6) [MIM:613224]: A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. Note=The disease is caused by mutations affecting the gene represented in this entry
SWISS-PROT	Leukemia, juvenile myelomonocytic (JMML) [MIM:607785]: An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages. Note=The disease is caused by mutations affecting the gene represented in this entry

NRAS cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene