Gene content
Symbol	NTN1 ( by HUGO)
Name	Netrin 1
Category	Other
Alias	Netrin 1 NTN1L Epididymis Tissue Protein Li 131P Netrin-1 Netrin 1 Mouse Homolog Of netrin-1
Cytogenetic band	NCBI: 17p13-p12    Ensembl: 17p13.1
Protein information	NET1_HUMAN Size: 604 amino acids Mass: 67748 Da Subunit: Binds to its receptors; DCC, DSCAM, UNC5A, UNC5B, UNC5C and probably UNC5D Tissue specificity: Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas. Expressed in epididymis (at protein level) [IMAGE] Pathway & Disease-focused RT2 Prof Function: UniProtKB/Swiss-Prot Summary: NET1_HUMAN, O95631 Function: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis Similarity: Contains 3 laminin EGF-like domains                        Contains 1 laminin N-terminal domain                        Contains 1 NTR domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR001134	Netrin_domain	Netrin, C-terminal	Domain
	IPR002049	EGF_laminin	Laminin-type EGF-like	Domain
	IPR008211	Laminin_N	Laminin, N-terminal	Domain
	IPR008979	Galactose-bd-like	Galactose-binding like	Domain
	IPR008993	TIMP-like_OB-fold	TIMP-like OB-fold	Domain
	IPR013032	EGF-like_CS	EGF-like region	Domain
Blocks	IPB001134	Netrin	Netrin, C-terminal
	IPB002049	Laminin-type EGF-like domain	Laminin-type EGF-like domain
	IPB008212	Laminin	Laminin, N-terminal 2

Gene Ontology
Type	Term	Evidence	Source	Pub
Molecular Function	protein binding	IPI	GOA	10102268

NTN1 cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene